The long-term costs and effects of tubal flushing with oil-based versus water-based contrast during hysterosalpingography

Research questionWhat are the long-term costs and effects of oil- versus water-based contrast in infertile women undergoing hysterosalpingography (HSG)?DesignThis economic evaluation a follow-up multicentre randomized controlled trial involved 1119 to HSG with (n = 557) or 562) Netherlands.ResultsIn oil-based group, 39.8% needed no other treatment, 34.6% underwent intrauterine insemination (IUI) 25.6% had IVF/intracytoplasmic sperm injection (ICSI) 5 years following HSG. In 35.0% 34.2% IUI 30.8% IVF/ICSI (P 0.113). After follow-up, using resulted equivalent (mean cost difference –€144; 95% confidence interval [CI] –€579 +€290; P 0.515) for 5% increase cumulative ongoing pregnancy rate compared (80% 75%, Relative Risk (RR) 1.07; CI 1.00–1.14). Similarly, –€50; –€576 +€475; 0.850) 7.5% live birth (74.8% 67.3%, RR 1.11; 1.03–1.20), making it dominant strategy. Scenario analyses suggest that medium is strategy up price €300.ConclusionOver 5-year an was associated rate, similar contrast.